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CURRICULUM VITAE

QUALIFICATIONS

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1993 MB BS Royal Free Medical School, University of London

1996 MRCP Royal College of Physicians of London

2005 DM University of Southampton

2007 CCT in Gastroenterology and General Medicine

2013 FRCP Royal College of Physicians of London

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CURRENT POSITIONS

Consultant Gastroenterologist at Royal Hampshire County Hospital, Hampshire Hospitals NHS Foundation Trust
Lead for Endoscopy at the Royal Hampshire County Hospital
Lead for Inflammatory Bowel Disease at the Royal Hampshire County Hospital
Bowel Cancer Screener Hampshire Bowel Cancer Screening Programme
Chair of the Mortality Surveillance Group Hampshire Hospitals NHS Foundation Trust

ENDOSCOPY EXPERIENCE

Gastroscopy including therapeutic UGI dilatation and stenting
Colonoscopy including polypectomy and endoscopic mucosal resection (EMR)
Bowel Cancer Screening
Flexible sigmoidoscopy
ERCP

RESEARCH INTERESTS

DM Thesis - Matrix degrading enzymes in IBD: dependence on TNFα and identification of IgG plasma cells as a novel source of MMP-3
Primary Investigator for multiple NIHR and industry funded trials in inflammatory bowel disease including IBD Bioresource, LUCENT UC, Profile, REACT-2, Legacy, SERENE UC, I-CARE, SPARE, PANTS, Pred-4

PUBLICATIONS

  1. White BE, Al-Badri A, Gordon JN. An 80 year old man with caecal ulceration. Gut. 2020 Oct;69(10):1761-1817

  2. Infliximab versus ciclosporin for steroid-resistant acute severe ulcerative colitis (CONSTRUCT): a mixed methods, open-label, pragmatic randomised trial. Williams JG, Alam MF, Alrubaiy L, Arnott I, Clement C, Cohen D, Gordon JN, Hawthorne AB, Hilton M, Hutchings HA, Jawhari AU, Longo M, Mansfield J, Morgan JM, Rapport F, Seagrove AC, Sebastian S, Shaw I, Travis SP, Watkins A. Lancet Gastroenterol Hepatol. 2016 Sep;1(1):15-24

  3. A 50-year-old woman with a recurrent oesophageal stricture. Akbar T, Al Badri A, Gordon JN. Gut. 2016 Apr;65(4):615

  4. Relapse after withdrawal from anti-TNF therapy for inflammatory bowel disease: an observational study, plus systematic review and meta-analysis. Kennedy NA, Warner B, Johnston EL, Flanders L, Hendy P, Ding NS, Harris R, Fadra AS, Basquill C, Lamb CA, Cameron FL, Murray CD, Parkes M, Gooding I, Ahmad T, Gaya DR, Mann S, Lindsay JO, Gordon JN, Satsangi J, Hart A, McCartney S, Irving P, Lees CW. Aliment Pharmacol Ther. 2016 Feb 19.

  5. Vaizey CJ, Gibson PR, Black CM, Nicholls RJ, Weston AR, Gaya DR, Shaji S, Shaw S, Lewis S, Bloom S, Gordon JN, Beale A, Arnott I, Campbell S, Fan T. Disease status, patient quality of life and healthcare resource use for ulcerative colitis in the UK: an observational study. Frontline Gastroenterol 2014 Jul;5(3):183-189

  6. Naghibi M, Ahmed A, Al Badri AM, Bateman AC, Shepherd HA, Gordon JN. The successful treatment of IgG4+ve colitis with adalimumab in a patient with IgG4 related sclerosing disease – a new subtype of aggressive colitis? J Crohns Colitis 2013 Apr1;7(3):e81-4

  7. Taylor NS, Gordon JN. Anaemia investigation in practice. Clin Med 2010;10(6);637

  8. Di Sabatino A, Saarialho-Kere U, Buckley MG, Gordon JN, Biancheri P, Rovedatti L, Corazza GR, Macdonald TT, Pender SL. Stromelysin-1 and macrophage metalloelastase expression in the intestinal mucosa of Crohn's disease patients treated with infliximab. Eur J Gastroenterol Hepatol. 2009 Sep;21(9):1049-55.

  9. Gordon JN, Prothero JD, Thornton CA, Pickard KM, Di Sabatino A, Goggin PM, Pender SL, Macdonald TT. CC-10004 but not thalidomide or lenalidomide inhibits lamina propria mononuclear cell TNF-α and MMP-3 production in patients with inflammatory bowel disease. Journal of Crohn’s and Colitis 2009;3(3):175-182

  10. Su W, Gordon JN, Barone F, Boursier L, Turnbull W, Mendis S, Dunn-Walters DK, Spencer J. Lamda light chain revision in the human intestinal IgA response. J Immunol 2008;181(2)

  11. Gordon JN, Pickard KM, Di Sabatino A, Goggin PM, Pender SL, MacDonald TT. IgG plasma cells in inflammatory bowel disease produce large quantities of stromelysin (MMP-3). Inflamm Bowel Dis. 2008;14(2):195-203

  12. Di Sabatino A, Pickard KM, Gordon JN, Beattie MR, Monteleone G, MacDonald TT. Evidence for the role of interferon-alpha production by dendritic cells in the Th1 response in celiac disease. Gastroenterology.  2007;133(4):1175-87

  13. Di Sabatino A, Pender SL, Jackson CL, Prothero JD, Gordon JN, Picariello L, Rovedatti L, Docena G, Monteleone G, Rampton DS, Tonelli F, Corazza GR, MacDonald TT. Functional modulation of Crohn’s disease myofibroblasts by anti-TNFα antibodies. Gastroenterology. 2007;133(1):137-49

  14. Gordon JN, Hossenbocus A. Massive obscure gastrointestinal haemorrhage in a middle-aged man. CME Gastroenterology 2006;7(3):89-90

  15. Gordon JN, MacDonald TT. Osteopontin: a new addition to the constellation of cytokines which drive T helper cell type 1 responses in Crohn's disease. Gut. 2005;54(9):1213-5

  16. Gordon JN, MacDonald TT. Bacterial Regulation of Intestinal Immune Responses. Gastroenterol Clin of North Am. 2005;34(3):401-12

  17. Gordon JN, Di Sabatino A, MacDonald TT. Immunopathogenesis of Crohn’s disease. JPEN J Parenter Enteral Nutr. 2005;29(4):S118-24

  18. Gordon JN, Di Sabatino A, Macdonald TT. The pathophysiologic rationale for biological therapies in inflammatory bowel disease. Curr Opin Gastroenterol. 2005;21(4):431-7

  19. Gordon JN, Green SR, Goggin  PM. Cancer Cachexia. QJM 2005;98(11):779-88

  20. Gunther U, Knight A, Holloway J, Chance V, Gordon JN, French R, Spencer J, Anderson G, Steer H, MacDonald TT. Phenotypic characterisation of CD3-7+ cells in developing human intestine and an analysis of their ability to differentiate into T cells. J Immunol. 2005;174(9):5414-22

  21. Boursier L, Gordon JN, Thiagamoorthy S, Edgeworth JD, Spencer J. Human intestinal IgA response is generated in the organized gut-associated lymphoid tissue but not in the lamina propria. Gastroenterology. 2005;128(7):1879-89

  22. Gordon JN, Trebble TM, Ellis RD, Duncan HD, Johns T, Goggin PM. Thalidomide in the treatment of cancer cachexia: A randomised placebo controlled trial. Gut. 2005;54(4):540-5

  23. Pickard KM, Bremner AR, Gordon JN, MacDonald TT. Immune responses in the gut. Best Pract Res Clin Gastreoenterol. 2004;18(2):271-285

  24. Gordon JN, Goggin PM. Thalidomide and derivatives. Emerging from the wilderness. Postgrad Med J 2003;79(929):127-32

  25. Gordon JN, MacDonald TT. Immunologically directed therapy in Crohn’s Disease. Hosp Med. 2003;64(12):708-12

  26. Gordon JN, Taylor A, Bennett PN. Lead Poisoning: case studies. Br J Clin Pharmacol. 2002;53(5):451-458

  27. Gordon JN. An unusual case of diarrhoea. Postgrad Med J 2000;76:512-513

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